Product Overview
PF-03814735 | T6936 | TargetMol Chemicals
CAS: 942487-16-3
Smiles: CC(=O)NCC(=O)N1[C@H]2CC[C@@H]1c1cc(Nc3ncc(c(NC4CCC4)n3)C(F)(F)F)ccc21
Formula: C23H25F3N6O2
Pathway: Angiogenesis|||Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors
Target: FAK|||VEGFR|||FLT|||Trk receptor|||Aurora Kinase
Receptor: N/A
Bioactivity: PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.
Molecular Weight: 474, 488
