Product Overview
PF-04418948 | T3306 | TargetMol Chemicals
CAS: 1078166-57-0
Smiles: COc1ccc2cc(OCC3(CN(C3)C(=O)c3ccc(F)cc3)C(O)=O)ccc2c1
Formula: C23H20FNO5
Pathway: GPCR/G Protein|||Immunology/Inflammation
Target: Prostaglandin Receptor
Receptor: N/A
Bioactivity: PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 μM. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM).
Molecular Weight: 409, 413
