Product Overview
PF-04802367 | T9611 | TargetMol Chemicals
CAS: 1962178-27-3
Smiles: COc(ccc(-c1c(C(NCCCn2ncnc2)=O)nco1)c1)c1Cl
Formula: C16H16ClN5O3
Pathway: PI3K/Akt/mTOR signaling|||Stem Cells
Target: GSK-3
Receptor: N/A
Bioactivity: PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. It shows desirable central nervous system (CNS) properties and potency. It is equally effective at inhibition of the two known GSK-3 isoforms (GSK-3α and GSK-3β) with IC50 values of 10.0 and 9.0 nM in mobility shift assays, respectively.
Molecular Weight: 361, 78
