Product Overview
PF-06372865 | T16489 | TargetMol Chemicals
CAS: 1614245-70-3
Smiles: CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1OC)S(=O)(=O)CC
Formula: C22H21FN4O3S
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: PF-06372865 is a high-affinity ligand at GABAA receptors containing α1/α2/α3/α5 subunits (Kis: 2.9 nM, 21 nM, 134 nM for α2, α1 PAM, α2 PAM, respectively). It also has a low affinity for α4/α6 subunits. PF-06372865 is an orally active and α2/α3/α5 subtype-selective GABAA positive allosteric modulator. PF-06372865 has the potential for epilepsy.
Molecular Weight: 440, 49
