Product Overview
PF-3644022 | T16501 | TargetMol Chemicals
CAS: 1276121-88-0
Smiles: C[C@@H]1CNc2c(sc3ccc4nc(ccc4c23)-c2ccc(C)nc2)C(=O)N1
Formula: C21H18N4OS
Pathway: MAPK|||Proteases/Proteasome
Target: p38 MAPK|||Serine Protease|||MAPK
Receptor: N/A
Bioactivity: PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production and has an anti-inflammatory effect. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) (IC50s: 53 nM and 5.0 nM, respectively).
Molecular Weight: 374, 46
