Product Overview
PF 429242 | T4317 | TargetMol Chemicals
CAS: 947303-87-9
Smiles: Cl.Cl.CCN(CC)Cc1ccc(cc1)C(=O)N(CCc1ccccc1OC)[C@@H]1CCNC1
Formula: C25H35N3O2·2HCl
Pathway: Membrane transporter/Ion channel|||Metabolism
Target: NPC1L1|||Lipid
Receptor: N/A
Bioactivity: PF-429242 is a competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM). It is selective for site 1 protease against a panel of serine proteases. PF-429242 inhibits rate of cholesterol synthesis in CHO cells (IC50 = 0.53 μM).
Molecular Weight: 482, 49
