Product Overview
PF-5006739 | T16507 | TargetMol Chemicals
CAS: 1293395-67-1
Smiles: Nc1nccc(n1)-c1c(ncn1C1CCN(Cc2ccon2)CC1)-c1ccc(F)cc1
Formula: C22H22FN7O
Pathway: Metabolism|||Stem Cells
Target: Casein Kinase
Receptor: N/A
Bioactivity: PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity. PF-5006739 decreases opioid drug-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner.
Molecular Weight: 419, 464
