Product Overview
PF-5274857 | T5465 | TargetMol Chemicals
CAS: 1373615-35-0
Smiles: Cc1cnc(c(C)c1)-c1cc(ncc1Cl)N1CCN(CC1)C(=O)CCS(C)(=O)=O
Formula: C20H25ClN4O3S
Pathway: Stem Cells
Target: Smo
Receptor: N/A
Bioactivity: PF-5274857 is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.PF-5274857 was found to effectively penetrate the blood-brain barrier and inhibit Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates. PF-5274857 was orally available and metabolically stable in vivo.
Molecular Weight: 436, 96
