Product Overview
PF-6274484 | T22396 | TargetMol Chemicals
CAS: 1035638-91-5
Smiles: COc(cc(c1c2)ncnc1Nc(cc1)cc(Cl)c1F)c2NC(C=C)=O
Formula: C18H14ClFN4O2
Pathway: Angiogenesis|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors
Target: EGFR
Receptor: N/A
Bioactivity: PF 6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively.
Molecular Weight: 372, 8
