Product Overview
PF-8380 | T3631 | TargetMol Chemicals
CAS: 1144035-53-9
Smiles: Clc1cc(Cl)cc(COC(=O)N2CCN(CCC(=O)c3ccc4[nH]c(=O)oc4c3)CC2)c1
Formula: C22H21Cl2N3O5
Pathway: Metabolism
Target: PDE
Receptor: N/A
Bioactivity: PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood). It modulates lysophosphatidic acid (LPA) levels in vivo/vitro by directly inhibiting autotaxin; reduces LPA levels both in plasma and at the site of inflammation.
Molecular Weight: 478, 33
