PF-915275 | T16510

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€209.00 - €2,193.00
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TMC-T16510
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Product Overview

PF-915275 | T16510 | TargetMol Chemicals

CAS: 857290-04-1

Smiles: Nc1cccc(NS(=O)(=O)c2ccc(cc2)-c2ccc(cc2)C#N)n1

Formula: C18H14N4O2S

Pathway: Metabolism|||Others

Target: Others|||Dehydrogenase

Receptor: N/A

Bioactivity: PF-915275 is an effective and selective inhibitor of human 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1, Ki = 2.3 nM, EC50 = 15 nM in vitro HEK293 cells). The dose-dependent effect of PF-915275 on conversion of cortisone to cortisol in primary human and monkey hepatocytes, with an EC50 of 20 and 100 nM, respectively.

Molecular Weight: 350, 4

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