Product Overview
PF-915275 | T16510 | TargetMol Chemicals
CAS: 857290-04-1
Smiles: Nc1cccc(NS(=O)(=O)c2ccc(cc2)-c2ccc(cc2)C#N)n1
Formula: C18H14N4O2S
Pathway: Metabolism|||Others
Target: Others|||Dehydrogenase
Receptor: N/A
Bioactivity: PF-915275 is an effective and selective inhibitor of human 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1, Ki = 2.3 nM, EC50 = 15 nM in vitro HEK293 cells). The dose-dependent effect of PF-915275 on conversion of cortisone to cortisol in primary human and monkey hepatocytes, with an EC50 of 20 and 100 nM, respectively.
Molecular Weight: 350, 4
