Product Overview
PG01 | T16516 | TargetMol Chemicals
CAS: 853138-65-5
Smiles: CC(C)c1ccc(NC(=O)C(N(C)C(=O)Cc2c[nH]c3ccccc23)c2ccccc2)cc1
Formula: C28H29N3O2
Pathway: Membrane transporter/Ion channel
Target: CFTR
Receptor: N/A
Bioactivity: PG01 is effective on ΔF508 (Ka of 0.3 μM). PG01 is also an effective CFTR Cl- channel potentiator. PG01 increases ΔF508-CFTR Cl- current after adding Forskolin. PG01 can correct gating defects of CFTR mutants, is effective on b>E193K, G970R, and G551D (CFTR mutants) with Kd values of 0.22 μM, 0.45 μM and 1.94 μM, respectively.
Molecular Weight: 439, 559
