Product Overview
PHA-767491 hydrochloride | T6940 | TargetMol Chemicals
CAS: 942425-68-5
Smiles: Cl.O=C1NCCc2[nH]c(cc12)-c1ccncc1
Formula: C12H12ClN3O
Pathway: Apoptosis|||Cell Cycle/Checkpoint|||PI3K/Akt/mTOR signaling|||Stem Cells
Target: Apoptosis|||GSK-3|||CDK
Receptor: N/A
Bioactivity: PHA-767491 is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM). It has ~20-fold selectivity against GSK3-β and CDK1/2, 50-fold selectivity against CDK5 and MK2, 100-fold selectivity against CHK2 and PLK1.
Molecular Weight: 249, 7
