Product Overview
Phenoxodiol | T16522 | TargetMol Chemicals
CAS: 81267-65-4
Smiles: Oc1ccc(cc1)C1=Cc2ccc(O)cc2OC1
Formula: C15H12O3
Pathway: Apoptosis|||DNA Damage/DNA Repair|||Proteases/Proteasome
Target: Apoptosis|||IAP|||Caspase|||Topoisomerase|||p53
Receptor: N/A
Bioactivity: Phenoxodiol activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner. Phenoxodiol also inhibits DNA topoisomerase II.
Molecular Weight: 240, 258