Product Overview
Phillyrin | T2854 | TargetMol Chemicals
CAS: 487-41-2
Smiles: COc1ccc(cc1OC)[C@@H]1OC[C@H]2[C@@H]1CO[C@@H]2c1ccc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c(OC)c1
Formula: C27H34O11
Pathway: Metabolism|||Microbiology/Virology|||PI3K/Akt/mTOR signaling
Target: P450|||Influenza Virus|||AMPK
Receptor: N/A
Bioactivity: Phillyrin is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activation. Phillyrin may be a new preventive agent of acute lung injury in the clinical setting, it potentially contributes to the suppression of the activation of MAPK and NF-κB pathways, it also has protective effects on H2O2-induced oxidative stress and apoptosis in PC12 cells.
Molecular Weight: 534, 558
