Product Overview
Phloretin | T2924 | TargetMol Chemicals
CAS: 60-82-2
Smiles: Oc1ccc(CCC(=O)c2c(O)cc(O)cc2O)cc1
Formula: C15H14O5
Pathway: GPCR/G Protein|||Metabolism
Target: SGLT|||transporter|||Endogenous Metabolite
Receptor: N/A
Bioactivity: Phloretin is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport. Phloretin is a dihydrochalcone, a type of natural phenols. It can be found in apple tree leaves and the Manchurian apricot. It promotes potent antioxidative activities in peroxynitrite scavenging and the inhibition of lipid peroxidation. It has been found to inhibit the growth of several cancer cells and induce apoptosis of B16 melanoma and HL60 human leukemia cells.
Molecular Weight: 274, 272
