Product Overview
Physalin A | TN4774 | TargetMol Chemicals
CAS: 23027-91-0
Smiles: C[C@@]12OC(=O)[C@@]3(O)CC[C@H]4C([C@H](O)C=C5CC=CC(=O)[C@]45C)[C@@]4(O)O[C@@]13[C@@H](C4=O)[C@]1(C)C[C@H]2OC(=O)C1=C
Formula: C28H30O10
Pathway: Angiogenesis|||Apoptosis|||Autophagy|||Chromatin/Epigenetic|||Endocrinology/Hormones|||Immunology/Inflammation|||JAK/STAT signaling|||MAPK|||NF-Κb|||Stem Cells
Target: ERK|||BCL|||p38 MAPK|||NF-κB|||Androgen Receptor|||ROS|||JAK|||JNK|||STAT|||p53|||Autophagy
Receptor: N/A
Bioactivity: Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate cancer cell growth through activation of cell apoptosis and downregulation of androgen receptor expression. Physalin A induces apoptosis via p53-Noxa-mediated ROS generation, and autophagy plays a protective role against apoptosis through p38-NF-κB survival pathway in A375-S2 cells.
Molecular Weight: 526, 5
