Product Overview
Pico145 | T16532 | TargetMol Chemicals
CAS: 1628287-16-0
Smiles: Cn1c2nc(Oc3cccc(OC(F)(F)F)c3)n(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O
Formula: C23H20ClF3N4O5
Pathway: Membrane transporter/Ion channel
Target: TRP/TRPV Channel
Receptor: N/A
Bioactivity: Pico145 is a remarkable inhibitor of TRPC1/4/5 channels. Pico145 inhibits ( )-englerin A-activated TRPC4/TRPC5 channels (IC50s: 0.349 and 1.3 nM in cells) It also shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8.
Molecular Weight: 524, 88