Product Overview
Pozanicline | T16563 | TargetMol Chemicals
CAS: 161417-03-4
Smiles: Cc1ncccc1OC[C@@H]1CCCN1
Formula: C11H16N2O
Pathway: Neuroscience
Target: AChR
Receptor: N/A
Bioactivity: Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction. Pozanicline selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2 nAChRs (Ki=16 nM). It shows high selectivity for α6β2 and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM .
Molecular Weight: 192, 262
