Product Overview
PP121 | T2415 | TargetMol Chemicals
CAS: 1092788-83-4
Smiles: Nc1ncnc2n(nc(-c3cnc4[nH]ccc4c3)c12)C1CCCC1
Formula: C17H17N7
Pathway: Angiogenesis|||Apoptosis|||Cytoskeletal Signaling|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors
Target: Apoptosis|||VEGFR|||Bcr-Abl|||PDGFR|||Src|||mTOR|||Hck
Receptor: N/A
Bioactivity: PP-121 is a multi-targeted inhibitor of PDGFR (IC50: 2 nM), Hck (IC50: 8 nM), mTOR (IC50: 10 nM), VEGFR2(IC50: 12 nM), Src (IC50: 14 nM) and Abl (IC50: 18 nM), also inhibits DNA-PK (IC50: 60 nM).
Molecular Weight: 319, 372
