Product Overview
PQR530 | T16567 | TargetMol Chemicals
CAS: 1927857-61-1
Smiles: C[C@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOCC1
Formula: C18H23F2N7O2
Pathway: PI3K/Akt/mTOR signaling
Target: PI3K|||mTOR
Receptor: N/A
Bioactivity: PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphorylation with IC50 values of 0.07 μM. It also showing antitumor activity.
Molecular Weight: 407, 426