Product Overview
PR-924 | T16568 | TargetMol Chemicals
CAS: 1416709-79-9
Smiles: C[C@@H](NC(=O)C1=C(C)c2ccccc2C1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1
Formula: C37H38N4O5
Pathway: Proteases/Proteasome|||Ubiquitination
Target: Proteasome
Receptor: N/A
Bioactivity: PR-924 is a selective inhibitor of tripeptide epoxyketone immunoproteasome subunit LMP-7 (IC50: 22 nM). PR-924 inhibits growth and triggers apoptosis in multiple myeloma (MM) cells. PR-924 has antitumor activities. PR-924 covalently modifies proteasomal N-terminal threonine active sites.
Molecular Weight: 618, 734
