Product Overview
Pralatrexate, (R)- | T25980 | TargetMol Chemicals
CAS: 1320211-70-8
Smiles: Nc1nc(N)c2nc(C[C@@H](CC#C)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1
Formula: C23H23N7O5
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: Pralatrexate, (R)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intracellularly, this agent is highly polyglutamylation and competes for the folate binding site of DHFR, blocking tetrahydrofolate synthesis.
Molecular Weight: 477, 481
