Product Overview
Prexasertib mesylate | T4310L2 | TargetMol Chemicals
CAS: 1234015-55-4
Smiles: CS(O)(=O)=O.COc1cccc(OCCCN)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
Formula: C19H23N7O5S
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: Prexasertib is a potent and selective Chk1/Chk2 inhibitor. Prexasertib increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia. LY2606368 causes replication catastrophe and antitumor effects through CHK1-dependent mechanisms. Treatment of cells with LY2606368 results in the rapid appearance of TUNEL and pH2AX-positive double-stranded DNA breaks in the S-phase cell population.
Molecular Weight: 461, 5
