Product Overview
PRLX-93936 | T36404 | TargetMol Chemicals
CAS: 903499-49-0
Smiles: CCOc1ccccc1-n1c(CN2CCNCC2)nc2ccccc2c1=O
Formula: C21H24N4O2
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: PRLX-93936 is an analog of erastin that has antitumor activity. It inhibits the hypoxia-inducible factor 1 (HIF-1) signaling pathway under hypoxic conditions (IC50 = 0.09 μM in a cell-based reporter assay). PRLX-93936 (1 μM) also inhibits hypoxia-induced increases in HIF-1α expression in ME-180 cervical cancer cells. It inhibits the growth of HT-1080 fibrosarcoma, OVCAR-5 ovarian cancer, BJELR tumorigenic primary fibroblast, and PANC-1 pancreatic cancer cells with IC50 values of less than 100 nM. PRLX-93936 inhibits tumor growth in PANC-1 and HT-1080 xenograft models when administered at a dose of 50 mg/kg and induces tumor regression when administered at a dose of 100 mg/kg.
Molecular Weight: 364, 449
