Product Overview
Procarbazine hydrochloride | T1488 | TargetMol Chemicals
CAS: 366-70-1
Smiles: Cl.CNNCc1ccc(cc1)C(=O)NC(C)C
Formula: C12H20ClN3O
Pathway: Cell Cycle/Checkpoint|||DNA Damage/DNA Repair
Target: DNA Alkylator/Crosslinker|||DNA/RNA Synthesis
Receptor: N/A
Bioactivity: Procarbazine Hydrochloride is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.
Molecular Weight: 257, 76
