Product Overview
Proguanil hydrochloride | T4382 | TargetMol Chemicals
CAS: 637-32-1
Smiles: Cl.CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1
Formula: C11H17Cl2N5
Pathway: Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Metabolism|||Microbiology/Virology|||Others
Target: Others|||Dehydrogenase|||DNA/RNA Synthesis|||Antifolate|||Parasite
Receptor: N/A
Bioactivity: Proguanil Hydrochloride is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, proguanil is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.
Molecular Weight: 290, 19
