Product Overview
PROTAC CDK9 degrader-2 | T17728 | TargetMol Chemicals
CAS: T17728
Smiles: O=C(C=C(C1=CC=CC=C1)O2)C3=C2C(OCC4=CN(CCCCCCCC(NC5=C(C(N(C6C(NC(CC6)=O)=O)C7=O)=O)C7=CC=C5)=O)N=N4)=C(O)C=C3O
Formula: C39H36N6O10
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1].
Molecular Weight: 748, 74
