PROTAC ERα Degrader-2 | T18605

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TMC-T18605
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Product Overview

PROTAC ERα Degrader-2 | T18605 | TargetMol Chemicals

CAS: 1351169-29-3

Smiles: C[C@@]12[C@](CC/C2=N\OCC(NCCOCCOCCNC([C@H](CC(C)C)NC([C@@H](O)[C@H](N)CC3=CC=CC=C3)=O)=O)=O)([H])[C@@]4([H])[C@](C5=CC=C(O)C=C5CC4)([H])CC1

Formula: C42H61N5O8

Pathway: Others

Target: Others

Receptor: N/A

Bioactivity: PROTAC ERα Degrader-2 comprises a cIAP1 ligand binding group, a linker and an estrogen receptor α (ERα) binding group. PROTAC ERα Degrader-2 is an ERα degrader. Maximal ERα degradation at 30 μM concentration in human mammary tumor MCF7 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].

Molecular Weight: 763, 96

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