Product Overview
Protosappanin A | TJS1779 | TargetMol Chemicals
CAS: 102036-28-2
Smiles:
Formula: C15H12O5
Pathway: Angiogenesis|||Apoptosis|||Chromatin/Epigenetic|||Immunology/Inflammation|||JAK/STAT signaling|||Microbiology/Virology|||Neuroscience|||NF-Κb|||Proteases/Proteasome|||Stem Cells
Target: NADPH-oxidase|||IL Receptor|||IκB/IKK|||TNF|||NF-κB|||TLR|||ROS|||COX|||HIV Protease|||JAK|||NO Synthase|||STAT
Receptor: N/A
Bioactivity: Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammation signal pathway; it exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Protosappanin A induces immunosuppression of rats heart transplantation targeting T cells in grafts via NF-kappaB pathway. Protosappanin A and protosappanin B have antimicrobial activity, they show both alone activities and resistance reversal effects of amikacin and gentamicin against MRSA. Protosappanin A shows strong effect against HIV-1 IN with an IC50 value of 12.6 uM.
Molecular Weight: 272, 25
