Product Overview
PS210 | T16670 | TargetMol Chemicals
CAS: 1221962-86-2
Smiles: OC(=O)C(C(CC(=O)c1ccc(cc1)C(F)(F)F)c1ccccc1)C(O)=O
Formula: C19H15F3O5
Pathway: PI3K/Akt/mTOR signaling
Target: PDK
Receptor: N/A
Bioactivity: PS210 is inactive against other protein kinases, including PDK1 downstream signaling components such as S6K, PKB/Akt, or GSK3. PS210 is a potent and selective PDK1 activator (Kd: 3 μM) and targets the PIF-binding pocket of PDK1. In cells, the prodrug of PS210 (PS423) acts as a substrate-selective inhibitor of PDK1, inhibiting the phosphorylation and activation of S6K.
Molecular Weight: 380, 319