Product Overview
PS315 | T16671 | TargetMol Chemicals
CAS: 1221964-50-6
Smiles: OC(=O)\C=C(\CCc1ccc(Cl)cc1)c1ccc(cc1)-c1ccccc1
Formula: C23H19ClO2
Pathway: Chromatin/Epigenetic|||Cytoskeletal Signaling
Target: PKC
Receptor: N/A
Bioactivity: PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity. PS315 is a derivative of PS48 and is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing displacement of the active site residue Lys111.
Molecular Weight: 362, 85