Product Overview
PX-12 | T2283 | TargetMol Chemicals
CAS: 141400-58-0
Smiles: CCC(C)SSc1ncc[nH]1
Formula: C7H12N2S2
Pathway: Metabolism
Target: Thioredoxin
Receptor: N/A
Bioactivity: PX-12 (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits tumor growth in animal models. Since high levels of Trx-1 have been associated with colorectal, gastric and lung cancers, PX-12 is indicated as a potential cancer treatment in combination with chemotherapy for patients with advanced metastatic cancer. Initial trials correlated doses of Px-12 with increased patient survival.
Molecular Weight: 188, 31
