Pyr10 | T16686

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TMC-T16686
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Product Overview

Pyr10 | T16686 | TargetMol Chemicals

CAS: 1315323-00-2

Smiles: Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-n1nc(cc1C(F)(F)F)C(F)(F)F

Formula: C18H13F6N3O2S

Pathway: Membrane transporter/Ion channel

Target: TRP/TRPV Channel

Receptor: N/A

Bioactivity: Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells (IC50: 0.72 μM) (IC50 of 13.08 μM for store-operated Ca2+ entry in BRL-2H3 cells) .

Molecular Weight: 449, 37

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