Product Overview
Quarfloxin | T16703 | TargetMol Chemicals
CAS: 865311-47-3
Smiles: CN1CCC[C@H]1CCNC(=O)c1cn2c3cc4ccccc4cc3oc3c(N4CCC(C4)c4cnccn4)c(F)cc(c23)c1=O
Formula: C35H33FN6O3
Pathway: Cell Cycle/Checkpoint|||DNA Damage/DNA Repair
Target: DNA/RNA Synthesis
Receptor: N/A
Bioactivity: Quarfloxin is a fluoroquinolone derivative with antineoplastic activity with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA template.
Molecular Weight: 604, 686