Product Overview
R547 | T6312 | TargetMol Chemicals
CAS: 741713-40-6
Smiles: COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(CC2)S(C)(=O)=O)nc1N
Formula: C18H21F2N5O4S
Pathway: Apoptosis|||Cell Cycle/Checkpoint|||PI3K/Akt/mTOR signaling|||Stem Cells|||Tyrosine Kinase/Adaptors
Target: Apoptosis|||GSK-3|||PKA|||CDK
Receptor: N/A
Bioactivity: R547 is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1.
Molecular Weight: 441, 45
