Product Overview
R8-T198wt | TP2128 | TargetMol Chemicals
CAS: 2305815-72-7
Smiles:
Formula: C111H211N59O26S
Pathway: N/A
Target: N/A
Receptor: N/A
Bioactivity: Cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. Inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. Also inhibits Pim-1-dependent growth of DU145 cells in vitro and in vivo. Displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM.
Molecular Weight: 2820, 33
