Product Overview
Radicicol | T16719 | TargetMol Chemicals
CAS: 12772-57-5
Smiles: [H][C@@]12C[C@@H](C)OC(=O)c3c(O)cc(O)c(Cl)c3CC(=O)\C=C\C=C/[C@@]1([H])O2
Formula: C18H17ClO6
Pathway: Cytoskeletal Signaling|||Metabolism
Target: HSP
Receptor: N/A
Bioactivity: Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50: 1 μM). Radicicol binds to the ATPase domain of Hsp90 and prevents maturation of Hsp90 clients, leading to proteasomal degradation.
Molecular Weight: 364, 78
