Product Overview
RAF265 | T6296 | TargetMol Chemicals
CAS: 927880-90-8
Smiles: Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3nc(c[nH]3)C(F)(F)F)ccc12
Formula: C24H16F6N6O
Pathway: Angiogenesis|||Apoptosis|||Autophagy|||MAPK|||Tyrosine Kinase/Adaptors
Target: Apoptosis|||Raf|||VEGFR|||Autophagy
Receptor: N/A
Bioactivity: RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM. Phase 2.
Molecular Weight: 518, 423
