Product Overview
Rauwolscine hydrochloride | T4429 | TargetMol Chemicals
CAS: 6211-32-1
Smiles: Cl.COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12
Formula: C21H27ClN2O3
Pathway: GPCR/G Protein|||Neuroscience
Target: Adrenergic Receptor
Receptor: N/A
Bioactivity: Rauwolscine, a natural alkaloid, is a specific and reversible α2-adrenergic receptor antagonist (Ki: 12 nM) [1]. It is a stereoisomer of yohimbine, which potently antagonizes both α1- and α2-adrenergic receptors [1]. Rauwolscine also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki: 14.3 nM) and as a weak partial agonist at 5-HT1A (IC50: 1.3 μM) [3]. The α2-adrenergic receptor has diverse physiological functions and antagonists like rauwolscine have numerous applications, including the modulation of mood and behavior [5].
Molecular Weight: 390, 91
