Product Overview
Rebamipide | T1562 | TargetMol Chemicals
CAS: 90098-04-7
Smiles: OC(=O)C(Cc1cc(=O)[nH]c2ccccc12)NC(=O)c1ccc(Cl)cc1
Formula: C19H15ClN2O4
Pathway: GPCR/G Protein|||Immunology/Inflammation|||Neuroscience|||oxidation-reduction
Target: Free radical scavengers|||COX|||Prostaglandin Receptor
Receptor: N/A
Bioactivity: Rebamipide is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis in the gastric mucosa. This agent also inhibits H. pylori-induced production of tumor necrosis factor (TNF) alpha and subsequent inflammation of the gastric mucosa. In addition, rebamipide scavenges oxygen-derived free radicals that potentially cause mucosal injury, and stimulates prostaglandin EP4 receptor gene expression followed by mucous secretion, thereby enhancing the gastric mucosal defense.
Molecular Weight: 370, 79
