Product Overview
Rebastinib | T2640 | TargetMol Chemicals
CAS: 1020172-07-9
Smiles: CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(nn3-c3ccc4ncccc4c3)C(C)(C)C)c(F)c2)ccn1
Formula: C30H28FN7O3
Pathway: Angiogenesis|||Apoptosis|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors
Target: Apoptosis|||FLT|||Bcr-Abl|||Src
Receptor: N/A
Bioactivity: DCC-2036 (Rebastinib) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC, HCK, FGR, FLT3, KDR, and Tie-2, and low activity to c-Kit.
Molecular Weight: 553, 598
