Product Overview
Resiquimod | T6964 | TargetMol Chemicals
CAS: 144875-48-9
Smiles: CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O
Formula: C17H22N4O2
Pathway: Immunology/Inflammation|||Microbiology/Virology|||Proteases/Proteasome
Target: HCV Protease|||TLR
Receptor: N/A
Bioactivity: Resiquimod is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect through the TLR signaling pathway by binding to and activating TLR7 and 8 mainly on dendritic cells, macrophages, and B-lymphocytes. This induces the nuclear translocation of the transcription activator NF-kB as well as activation of other transcription factors. This may lead to an increase in mRNA levels and subsequent production of cytokines, especially interferon-alpha (INF-a) and other cytokines, thereby enhancing T-helper 1 (Th1) immune responses. In addition, topical application of resiquimod appears to activate Langerhans' cells, leading to an enhanced activation of T-lymphocytes.
Molecular Weight: 314, 389
