Product Overview
RGB-286638 free base | T2378 | TargetMol Chemicals
CAS: 784210-88-4
Smiles: COCCN1CCN(Cc2ccc(cc2)-c2n[nH]c3-c4cccc(NC(=O)NN5CCOCC5)c4C(=O)c23)CC1
Formula: C29H35N7O4
Pathway: Angiogenesis|||Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||JAK/STAT signaling|||MAPK|||PI3K/Akt/mTOR signaling|||Stem Cells
Target: GSK-3|||MEK|||JAK|||CDK
Receptor: N/A
Bioactivity: RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 and cyclin D3-CDK6.
Molecular Weight: 545, 644
