Product Overview
Rhynchophylline | T6S0659 | TargetMol Chemicals
CAS: 76-66-4
Smiles: CC[C@H]1CN2CC[C@@]3([C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC)C(=O)Nc1ccccc31
Formula: C22H28N2O4
Pathway: Membrane transporter/Ion channel|||Metabolism|||NF-Κb
Target: Calcium Channel|||NF-κB
Receptor: N/A
Bioactivity: 1. Rhynchophylline can protect against ischemic damage, probably via regulating the Akt/mTOR pathway. 2. Rhynchophylline can protect against glutamate-induced neuronal death, can inhibit MA impairment in cultured neurons in vitro. 3. Rhynchophylline and isorhynchophylline have a non-competitive antagonistic effect on the NMDA-type ionotropic glutamate receptors, suggest that these alkaloids exert their protective action against ischemia-induced neuronal damage by preventing NMDA, muscarinic M1, and 5-HT2 receptors-mediated neurotoxicity during ischemia.
Molecular Weight: 384, 476
