Product Overview
RO1138452 | T4436 | TargetMol Chemicals
CAS: 221529-58-4
Smiles: CC(C)Oc1ccc(Cc2ccc(NC3=NCCN3)cc2)cc1
Formula: C19H23N3O
Pathway: GPCR/G Protein|||Immunology/Inflammation|||Others
Target: Others|||Prostaglandin Receptor
Receptor: N/A
Bioactivity: RO1138452 is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3). It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Likewise, it inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of about 1.5 nM. At levels between 2-20 mg/kg in rats, CAY10441 shows significant analgesic activity in standard antinociceptive assays [1].
Molecular Weight: 309, 413