Product Overview
RO8994 | T3517 | TargetMol Chemicals
CAS: 1309684-94-3
Smiles: COc1cc(ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21)C(N)=O
Formula: C31H31Cl2FN4O4
Pathway: Apoptosis|||Ubiquitination
Target: Mdm2|||E1/E2/E3 Enzyme|||p53
Receptor: N/A
Bioactivity: RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays).
Molecular Weight: 613, 51
