Product Overview
Rosmanol | T7033 | TargetMol Chemicals
CAS: 80225-53-2
Smiles: CC(C)c1cc2[C@H](O)[C@H]3OC(=O)[C@@]4(CCCC(C)(C)[C@H]34)c2c(O)c1O
Formula: C20H26O5
Pathway: Immunology/Inflammation|||Neuroscience|||oxidation-reduction
Target: Antioxidant|||COX
Receptor: N/A
Bioactivity: Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activity in mouse models of antinociception, antidepressant and anxiolysis. Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells. Rosmanol has anti-inflammatory activity, it potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-kappaB, STAT3 and C/EBP signaling pathways.
Molecular Weight: 346, 423
