Product Overview
Ruscogenin | T6S1256 | TargetMol Chemicals
CAS: 472-11-7
Smiles: C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC=C5C[C@@H](O)C[C@@H](O)[C@]5(C)[C@H]4CC[C@]23C)O[C@]11CC[C@@H](C)CO1
Formula: C27H42O4
Pathway: Immunology/Inflammation|||NF-Κb
Target: NOS|||NF-κB|||NOD-like Receptor (NLR)
Receptor: N/A
Bioactivity: 1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, 2. Ruscogenin inhibited adhesion of leukocytes to a human umbilical vein endothelial cell line (ECV34) injured by tumor necrosis factor-alpha (TNF-alpha) in a concentration-dependent manner. 3. Ruscogenin significantly attenuate LPS-induced acute lung injury via inhibiting expressions of TF and iNOS and NF-kappa B p65 activation.
Molecular Weight: 430, 629
