Product Overview
(S, R, S)-AHPC-C2-PEG4-N3 | T18662 | TargetMol Chemicals
CAS: T18662
Smiles: CC(C)([C@H](NC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)C(N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)C
Formula: C33H49N7O8S
Pathway: Others
Target: Others
Receptor: N/A
Bioactivity: (S, R, S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S, R, S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S, R, S)-AHPC-C2-PEG4-N3 can be used in the synthesis of vRucaparib-TP4. vRucaparib-TP4 a highly potent PARP1 degrader with a half-maximal degrading concentration (DC50) of 82 nM[1].
Molecular Weight: 703, 85
